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KMID : 0438219740110010511
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Korea University Medical Journal
1974 Volume.11 No. 1 p.511 ~ p.526
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An Experimental Study on Histological Changes in the Gonads, and Changes in Content of Water and Electrolytes in the Tissue of the Uterus and Aorta of Mature Female Rabbits by Resepine Adrministration
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張相淑/Chang, Sang Sook
李壽鍾/Lee, Soo Chong
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Abstract
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Reserpine, one of the tranquilizers, decreases the reflex of neurologic stimulation. It is for this reason, widely used as an anti-hypertensive drug. It also decreases the reflex mechanism of all the nervous functions by depleting catecholamine or serotonin that seems to help the physiological neurotransmitter or neuromeduallary function. In addition, reserpine acts on the central nervous system via hypothalamic axis. It inhibits the release of FSH and LH and stimulates the reiease of prolactin or inhibits the ´releaseinhibition´ mechanism. When the drug is used in a long-term or in a large dose, some untoward side effects arise.
An attempt was made to clarilfy the effect of reserpine on water and electrolytes in the tissue of the uterus, the target organ of the overy and aortic tissue of mature female rabbits weighing around 2.0 kg of body weight.
A group of rabbits preconditioned with 50 L U. /kg of HCG. and another with 1.5 mg/kg of reserpine plus 50 L U. /kg of HCG were observed in 24 hours after conditioning.
The results obtained wereas follows:
1. The HCG preconditioned mature female rabbits showed acceleration of maturation of the follicles and ovulation in the ovaries, the reserpine plus HCG preconditioned group showed corpus luteum formation and cystic change of the corpus luteum.
2. The electrolyte levels in the serum of HCG preconditioned rabbits showed an increase of potass-
ium and calcium levels, and a decrease in chloride and magnesium levels. The level of magnesium in
<-the serum of the reserpine plus HCG preconditioned group was remarkably decreased.
3.. The :water, sodium, and calcium-levels in. the uterine. ,-tissue of : the HCG, preconditioned mature
female rabbits showed an increase in content compared to the normal group and a decrease in chloide, and magnesium. In the reserpine plus HCG preconditioned group, water was increased and chloride, poatssium, and magnesium levels were remarkably decreased, while reserpine administration induced no suppression change of electrolytes in the uterine tissue.
4. The water content in the aortic tissue was decreased, and sodium, potassium, and calcium levels were increased in the HCG preconditioned mature female rabbits. The water, sodium, calcium, and magnesium levels were increased and sodium and potassium levels were decreased in the reserpine plus HCG preconditioned group. The changes of water, sodium, and potassium levels in the HCG preconditioned group were inhibited by the reserpine administration.
5. The water contents in aortic tissue of the normal HCG preconditioned, and reserpine plus HCG preconditioned rabbits were lower than that of the uterine tissue.
6. The chloride content in the aortic tissue of normal female rabbits was higher than that of the uterus and much higher in HCG and reserpine plus HCG preconditioned groups.
7. The sodium content in the aortic tissue of the normal, HCG, and reserpine plus HCG preconditioned group were higher than that of the uterine tissue.
& Although the potassium content in the aortic tissue of the normal and HCG preconditioned were lower than that of the uterus, no appreciable difference was noted in the reserpine plus HCG preconditioned group.
9. The calcium content in the aortic tissue of the normal was higher than that of the uterine tissue and the HCG preconditioned and reserpine plus HCG preconditioned groups showed even more higher levels.
10. While the magnesium content in the aortic tissue of the normal rabbits was lower than that of the uterus, it´s content was increased in the HCG and reserpine plus HCG preconditioned groups.
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KEYWORD
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